Voxel Based Morphometry
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Voxel Based Morphometry (VBM) was originally developed by John Ashburner and colleagues at the Functional Imaging Laboratory (FIL), University College London in 2000. Details of the method can be found in the original 1999 paper: File:Voxel-Based Morphometry - The Methods.pdf
For help getting started with VBM analysis take a look at Nia's Guide to FSL VBM and Nia's Guild to SPM VBM.